basic FUNCTION
| having ligand-dependent nuclear receptor activity, and involved in signal transduction |
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plays a crucial role in cone development by directly regulating multiple cone genes |
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pluripotent molecular player in constitutive and adaptive astrocyte physiology, exerting a bi-directional regulation of IL6 in resting and reactive astrocytes |
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cholesterol signalling through increased RORA expression stimulates chondrocyte hypertrophy and partially mediates responses of cartilage to actin dynamics |
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play a critical role in responses to cellular stress |
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contributes to the basal expression of FGF21 |
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involved in regulating the Akt2-AMPK signaling pathways in the context of lipid homeostasis in skeletal muscle |
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operates at the nexus of pathways controlling the association between lipid homeostasis (lipogenesis, and fatty acid oxidation), Akt2 signaling (glucose tolerance and uptake) and AMPK signaling |
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RORA is a key molecular player in hypoxia, protecting neurons through its dual action in neurons and astrocytes |
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role of RORA in diverse pathological processes including oxidative stress-induced apoptosis and cerebral hypoxia |
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plays an important role in regulation of the circadian rhythm and metabolism |
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is a retinoid-related orphan nuclear receptor that regulates inflammation, lipid metabolism, and cellular differentiation of several non-epithelial tissues |
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RORA is a transcriptional activator of insulin, suggesting novel therapeutic opportunities for management of the diabetes |
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RORA and NR1D1 coordinately regulate the expression of the positive arm of the circadian rhythm feedback loop ( |
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is a potent tumor suppressor that reduces cell proliferation and inhibits tumor growth |
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nuclear melatonin receptor RORA is a novel endogenous protective receptor against MI/R injury and an important mediator of melatonin-exerted cardioprotection |
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plays important roles in lipid, glucose metabolism, as well as the inflammatory response |
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RORA-induced ER stress response potentially contributes to the adipose tissue inflammation that can be mitigated by treatment with chemical chaperones |
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is an important regulator of various biological processes, including cerebellum development, circadian rhythm and cancer |
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has a pivotal role in the regulation of hepatic lipid homeostasis |
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RORC, and RORA are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation |
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overlapping role of RORC and RORA in human Th17 cell differentiation through regulation of a defined common set of Th17 genes |
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