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FLASH GENE
Symbol NUP133 contributors: mct - updated : 25-09-2019
HGNC name nucleoporin 133kDa
HGNC id 18016
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 4170 - 1156 - 2007 17768364
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal domain whose crystal structure reveals a seven-bladed beta-propeller, which although largely dispensable for nuclear pore complex assembly, is required for efficient anchoring of the dynein/dynactin complex to the nuclear envelope in prophase (
  • a C-terminal domain responsible for its interaction with its subcomplex through NUP107
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • with NUP107, form elongated structures that interact tightly via a compact interface in tail-to-tail fashion
  • major alpha-helical building blocks of the nuclear pore complex scaffold
  • is required for proper nuclear pore basket assembly and dynamics in embryonic stem cells
  • NUP133 and NUP153 play different roles in assembling the nuclear pore complex (NPC) on membrane fenestrations
  • likely required for proper glomerular structure and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CENPF
  • NUP133 interacts with CENPF both at nuclear pores in prophase and at kinetochores in mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GAMOS8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS