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FLASH GENE
Symbol NASP contributors: mct - updated : 09-09-2013
HGNC name nuclear autoantigenic sperm protein (histone-binding)
HGNC id 7644
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing initiation site 3302 85.2 788 testis, spermatocytes, spermatid, spermatozoid 2012 2196553
  • isoform 2 tNASP, testicular NASP
  • characterization of a sperm NASP
  • critical for the survival of prostate cancer cells, suggesting that targeting tNASP expression can lead to a new approach for prostate cancer treatment
  • its role is to provide the functional link between linker histones and cell cycle progression during meiosis
    • 14 splicing initiation site 2294 - 449 all mitotic cells (adult embryonic) during five phases 2012 2196553
  • isoform 3 sNASP, somatic NASP
  • characterization of the histone H1-binding protein as a cell-cycle regulated somatic protein
  • possesses a unique binding specificity in that it forms specific complexes with both histone H1 and histones H3/H4
  • efficiently promoted the assembly of nucleosomes containing the conventional H3.1, H3.2, H3.3, or centromere-specific CENPA
    • - splicing initiation site 3396 - 790 - 2012 2196553
    13 - 3109 - 724 - 2012 2196553
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • TRP1-2-3 (tetratricopeptid) repeats
  • from coiled coil
  • glu-rich (acidic)
  • leucine-zipper
  • nuclear localization signal
    • HOMOLOGY
    interspecies ortholog to murine Nasp
    homolog to C.elegans F58G11.1A
    homolog to xenopus N11N2
    Homologene
    FAMILY nuclear autoantigenic sperm protein (NASP) family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text tNASP : Golgi and acrosome nucleus, 5NASP:nuclear localization
    basic FUNCTION
  • transporting histones into the nucleus of dividing cells (isoform 3)
  • directly promotes nucleosome assembly, providing compelling evidence that sNASP is a bona fide histone chaperone for H3.H4
  • specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain
  • unique genuine chaperone for histone H1
    • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • GTP
    • protein
  • binding to H1 histones
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • TRA2B is involved in splicing processes of NASP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS