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FLASH GENE
Symbol MT-ND1 contributors: mct/ - updated : 19-08-2009
HGNC name mitochondrially encoded NADH dehydrogenase 1
HGNC id 7455
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
mono polymer heteromer , complex
HOMOLOGY
interspecies ortholog to murine Mt-Nd1
homolog to C.elegans F15A2.4
Homologene
FAMILY
  • complex I subunit 1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • catalysing reduction of ubiquinone on ubiquinol by NADH in the respiratory chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the forty one subunits of complex I, located in the hydrophobic fragment
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • rotenone and its analogs
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHON , MELAS , MTCMH5D , WFSMT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    point mutations in sudden infant death syndrome
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
  • Alzheimer
  • Parkinson
  • Variant & Polymorphism 4216T>C increases the risk of Parkinson disease among healthy aged people
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS