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FLASH GENE

Symbol

MOV10

contributors: mct/shn - updated : 29-09-2015

HGNC name	Mov10, Moloney leukemia virus 10, homolog (mouse)
HGNC id	7200

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020963 21 - 3653 NP_066014 115 1003 - 2009 19665004 NM_001130079 21 - 3538 NP_001123551 115 1003 - 2009 19665004 NM_001286072 22 - 4515 NP_001273001 - 947 - 2009 19665004

EXPRESSION

Rna function	highly in testis and ovary
Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       moderately Lymphoid/Immune thymus       highly Nervous brain       moderately Reproductive male system prostate     moderately Respiratory lung       highly   respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage
cell lines	undifferentiated F9 ambryonal carcinoma cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal region may be responsible for the formation of MOV10–TERT complex (Nakano 2009)
	NP (ATP) binding domain
	DEAG Box

HOMOLOGY

interspecies	ortholog to Mov10, Mus musculus
	ortholog to Mov10, Rattus norvegicus
	homolog to drosophila Armitage
	ortholog to MOV10, Pan troglodytes

Homologene

FAMILY	RNA helicase superfamily-2
	argonaute-associated proteins family
	SDE3 subfamily

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nucleus,chromatin/chromosome
text	both APOBEC3G and MOV10 have been found to co-localize with AGO1 and AGO2 in P-bodies and stress granules
	MOV10 and APOBEC3G (A3G) localize to cytoplasmic granules called processing bodies (P bodies)

basic FUNCTION	may be an helicase with an important function in development and in control of cell proliferation
	required to mediate microRNA-guided mRNA cleavage
	may play a role in RNA-directed transcription
	involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA
	may have some role(s) in normal cells and it may regulate telomerase activity to bind to TERT and telomere DNA
	preferentially expressed in telomerase-positive organs and the cancer cells, and physically and functionally associated with TERT and telomere
	has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection
	involved in transcriptional silencing by PcG complexes
	can potently inhibit HIV-1 replication at multiple stages
	may be potentially a component of a cellular pathway or process that selectively regulates the replication of endogenous retroelements in somatic cells
	putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibiting retrovirus replication
	may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements
	MOV10 contributes to the cellular control of LINE-1 replication
	MOV10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide

PHYSIOLOGICAL PROCESS

development

text	a putative RNA helicase

PATHWAY

metabolism

signaling

a component

Polycomb-repressive complex 1, PRC1

INTERACTION

DNA	chromatin in an RNA-dependent manner

RNA

small molecule	nucleotide,
	ATP

protein	Polycomb-repressive complex 1, PRC1
	APOBEC3G binds to a domain at the C terminus in MOV10, where it competitively inhibits the binding of AGO2 to that same domain
	MOV10 functions in UPF1-mediated mRNA degradation as an RNA clearance factor to resolve structures and displace proteins from 3prime UTRs
	FMR1 associates with the RNA helicase MOV10, also associated with the microRNA pathway, in an RNA-dependent manner and facilitates MOV10 association with RNAs in brain and cells, suggesting a cooperative interaction
	RNA helicase MOV10 plays a role in WNT5A synthesis and secretion
	HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev

cell & other

REGULATION

repressed by

acyclic AMP,retinsic acid

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS