Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MOV10 contributors: mct/shn - updated : 29-09-2015
HGNC name Mov10, Moloney leukemia virus 10, homolog (mouse)
HGNC id 7200
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3653 115 1003 - 2009 19665004
21 - 3538 115 1003 - 2009 19665004
22 - 4515 - 947 - 2009 19665004
EXPRESSION
Rna function highly in testis and ovary
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   moderately
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   highly
 respiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines undifferentiated F9 ambryonal carcinoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region may be responsible for the formation of MOV10–TERT complex (Nakano 2009)
  • NP (ATP) binding domain
  • DEAG Box
  • HOMOLOGY
    interspecies ortholog to Mov10, Mus musculus
    ortholog to Mov10, Rattus norvegicus
    homolog to drosophila Armitage
    ortholog to MOV10, Pan troglodytes
    Homologene
    FAMILY
  • RNA helicase superfamily-2
  • argonaute-associated proteins family
  • SDE3 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,chromatin/chromosome
    text
  • both APOBEC3G and MOV10 have been found to co-localize with AGO1 and AGO2 in P-bodies and stress granules
  • MOV10 and APOBEC3G (A3G) localize to cytoplasmic granules called processing bodies (P bodies)
  • basic FUNCTION
  • may be an helicase with an important function in development and in control of cell proliferation
  • required to mediate microRNA-guided mRNA cleavage
  • may play a role in RNA-directed transcription
  • involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA
  • may have some role(s) in normal cells and it may regulate telomerase activity to bind to TERT and telomere DNA
  • preferentially expressed in telomerase-positive organs and the cancer cells, and physically and functionally associated with TERT and telomere
  • has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection
  • involved in transcriptional silencing by PcG complexes
  • can potently inhibit HIV-1 replication at multiple stages
  • may be potentially a component of a cellular pathway or process that selectively regulates the replication of endogenous retroelements in somatic cells
  • putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibiting retrovirus replication
  • may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements
  • MOV10 contributes to the cellular control of LINE-1 replication
  • MOV10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide
    PHYSIOLOGICAL PROCESS development
    text a putative RNA helicase
    PATHWAY
    metabolism
    signaling
    a component
  • Polycomb-repressive complex 1, PRC1
  • INTERACTION
    DNA chromatin in an RNA-dependent manner
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • Polycomb-repressive complex 1, PRC1
  • APOBEC3G binds to a domain at the C terminus in MOV10, where it competitively inhibits the binding of AGO2 to that same domain
  • MOV10 functions in UPF1-mediated mRNA degradation as an RNA clearance factor to resolve structures and displace proteins from 3prime UTRs
  • FMR1 associates with the RNA helicase MOV10, also associated with the microRNA pathway, in an RNA-dependent manner and facilitates MOV10 association with RNAs in brain and cells, suggesting a cooperative interaction
  • RNA helicase MOV10 plays a role in WNT5A synthesis and secretion
  • HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev
  • cell & other
    REGULATION
    repressed by acyclic AMP,retinsic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS