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FLASH GENE
Symbol LIN7C contributors: mct - updated : 09-06-2009
HGNC name lin-7 homolog C (C. elegans)
HGNC id 17789
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4866 22 197 - 1998 9753324
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrainhindbraincerebellum  
 braindiencephalonhypothalamus  
 braindiencephalonthalamusnuclei 
Olfactoryolfactory bulb    
Reproductivefemale systemuterus  highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
Text
  • in the developing cerebral cortex
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans Lin7
    Homologene
    FAMILY
  • lin-7 family
  • p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm
    text
  • localizing in synapses
  • localized to the apical domain of neural progenitor cells
  • colocalizes with adaptor proteins DLG4, ANO2, and MPP4 at the ribbon synapses
  • basic FUNCTION
  • involved in regulation of synaptic function and synapse assembly
  • plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterotrimerizing with CASK, MINT1
  • dimer of MPP7 with LIN7A or LIN7C associates with DLG1 through an interaction requiring the amino-terminal L27 domain of MPP7
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HTR2C
  • DLG4/LIN7C assembly and maintenance at synaptic membranes is coordinated by MPP4
  • interacting with CASK and DLG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in oral squamous cell carcinoma (OSCC) metastasis (Onda 2007)
    constitutional        
    of either CDH2 or LIN7C disrupts neural tube formation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS