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FLASH GENE

Symbol

IL18RAP

contributors: mct - updated : 06-06-2008

HGNC name	interleukin 18 receptor accessory protein
HGNC id	5989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003853 12 - 2668 NP_003844 68.3 599 - 2008 18439550

EXPRESSION

Rna function	testis
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen           thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune macrophage Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 14-amino acid signal peptide
	a 342-amino acid extracellular (Ig superfamily-like) segment
	three Ig like domains
	three glycosylation potential sites
	single transmembrane region
	a 222-amino acid cytoplasmic domain

mono polymer

heteromer , dimer

isoforms

Precursor

HOMOLOGY

interspecies

ortholog to murine Il18rap

Homologene

FAMILY

interleukin-1 receptor (IL-1R) family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	required for induction of NFkappaB activity and for activation of c-Jun N-terminal kinase
	pleiotropic cytokine involved in the regulation of both innate and adaptive immunity and playing a key role in the autoimmune, inflammatory and infectious diseases
	essential for IL-18 signal transduction and ligand binding affinity to IL-18Ralpha receptor chain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	Th1 immune response

PATHWAY

metabolism

signaling

signal transduction

a component	heterodimerizing with IL18R1
	component of IL18 receptor

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

IFN-alpha,IL-12

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn's disease and ulcerative colitis

Variant & Polymorphism SNP	increasing the risk of Crohn's disease and ulcerative colitis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS