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FLASH GENE
Symbol HES6 contributors: mct - updated : 28-01-2012
HGNC name hairy and enhancer of split 6 (Drosophila)
HGNC id 18254
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1380 24.2 222 - 2007 17300753
4 - 1386 - 224 - 2007 17300753
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
Reproductivefemale systemovary  highly
Skin/Tegumentskin   highly
Visualeye   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in cochlea
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 1 basic helix-loop-helix (BHLH) domain
  • a orange domain
  • a WRPW motif, sufficient for acceleration of proteolysis as its fusion to two heterologous proteins, and mediating proteasomal degradation
  • HOMOLOGY
    interspecies ortholog to murine Hes6
    homolog to Xenopus Xl.209
    Homologene
    FAMILY basic helix-loop-helix family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressing HES1 from repressing transcription
  • transcriptional repressor of genes that require a BHLH protein for their transcription
  • may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1
  • promoting, instead of inhibiting, neuronal and myogenic differentiation and probably through antagonizing the HES1 and HES5 functions
  • in the inner ear, might be involved in the differentiation of hair cells and promotes neuronal differentiation in the neural plate, the retina and in the cortex
  • basic helix-loop-helix transcription factor that functions in the differentiation of pluripotent progenitor cells and during tumorigenesis
  • estrogen-regulated gene in breast cancer cells
  • regulate proliferating cell fate in development and is known to be expressed in developing muscle
  • novel role in actin cytoskeletal dynamics in post mitotic myoblasts
  • important role for HES6 in supporting survival of glioma cells, as evidenced by reduction of cancer cell proliferation and migration after HES6 silencing
  • is important for glioma cell proliferation and migration, and may have a role in angiogenesis
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with CREBBP, one of the key components of (PML-NB), via its basic domain
  • inhibitor of HES1 during neuronal development
  • direct transcriptional target of the myogenic transcription factors MYOD1 and MYF5, indicating that it is integral to the myogenic transcriptional program
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in recurrent grade 2 astrocytomas and grade 2 or 3 oligodendrogliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    could be important for the development of novel anticancer drugs
    ANIMAL & CELL MODELS