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FLASH GENE
Symbol ETV2 contributors: mct/npt/shn - updated : 09-12-2013
HGNC name ets variant gene 2
HGNC id 3491
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1490 36.5 342 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Mus musculusAdult
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extremely potent N-terminal transactivation domain comprised of amino acids 1-157 (De Haro 2002)
  • ETS DNA binding motif, PEA3 group (conserved ETS domain is responsible for DNA binding activity of the ETS protein family) (Ferdous 2009)
  • HOMOLOGY
    interspecies ortholog to Etv2, Mus musculus
    ortholog to etv2, Danio rerio
    ortholog to Etv2, rattus norvegicus
    ortholog to ETV2, Pan troglodytes
    Homologene
    FAMILY
  • ETS family of transcription factor
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text nuclear protein whose intracellular localization is dependent on a portion of the ETS domain, namely ER71 amino acids 276-315 (De Haro 2002)
    basic FUNCTION
  • binding to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'
  • may perform important functions in the developing and adult testis as well as in testicular germ cell tumorigenesis (De Haro 2002)
  • required for the formation of myeloid but not erythroid cellsand in the absence of ETV2 the number of granulocytes and macrophages is greatly reduced (Sumanas 2008)
  • a critical regulator of mesodermal fate decisions that acts to specify the hematopoietic and endothelial lineages at the expense of cardiac lineages
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to sequences containing the consensus pentanucleotide 5'-CGGA(AT)-3'
    RNA
    small molecule
    protein
  • Testis-specific gene A, TSGA
  • OVOL2 directly interacted with ETV2, but not with ETS1 or ETS2, in the nucleus
  • KDM1A-dependent shutdown of ETV2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Er71 mouse mutant embryos are nonviable and lack hematopoietic and endothelial lineages