basic FUNCTION
| mediator of EBV effects on B lymphocytes |
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promotes B cell localization in the outer follicle and helps position B cells appropriately for mounting T-dependent antibody responses (Pereira 2009) |
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expression of GPR183 by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses |
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mediates B cell migration toward the outer areas of follicles and to bridging channels of the spleen independent of both CXCR5 and CCR7 |
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role in B cell migration and localization |
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essential role for GPR183 in CD4(+) Dendritic cells positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens |
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potential negative regulatory role for GPR183 in balancing TLR-mediated responses to foreign and to self nucleic acids that may precipitate autoimmunity |
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plays a role in T cell-dependant antibody response and B cell migration |
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role in astrocyte function, suggesting that modulation of this receptor may be beneficial in neuroinflammatory disorders |
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oxysterols and GPR183 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis |
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is an important chemotactic receptor that is involved in proper B-cell T-cell interactions |
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GPR183 directs B-cell migration in the lymphoid follicles in response to its endogenous ligands, oxysterols |
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is a promoter of B-cell malignancies |
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mediator of CNS autoimmunity with contribution to the migration of autoreactive T cells into inflamed organs |
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governs localization of T cells, B cells, and dendritic cells (DCs) during immune responses in secondary lymphoid organs |
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role for GPR183 in promoting efficient thymic central tolerance |