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FLASH GENE
Symbol GPR183 contributors: mct - updated : 16-01-2018
HGNC name G protein-coupled receptor 183
HGNC id 3128
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1801 41.1 361 - 2008 18628402
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node     Homo sapiens
 spleen     Homo sapiens
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
     
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
Nervousastrocyte Homo sapiens
cell lineage
cell lines promeylocytic and histiocytic cell line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
  • rhodopsin-like subfamily of 7TM receptors
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text is expressed in mature B cells and increases in expression early after activation, before being downregulated in germinal centre B cells (Pereira 2009)
    basic FUNCTION
  • mediator of EBV effects on B lymphocytes
  • promotes B cell localization in the outer follicle and helps position B cells appropriately for mounting T-dependent antibody responses (Pereira 2009)
  • expression of GPR183 by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses
  • mediates B cell migration toward the outer areas of follicles and to bridging channels of the spleen independent of both CXCR5 and CCR7
  • role in B cell migration and localization
  • essential role for GPR183 in CD4(+) Dendritic cells positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens
  • potential negative regulatory role for GPR183 in balancing TLR-mediated responses to foreign and to self nucleic acids that may precipitate autoimmunity
  • plays a role in T cell-dependant antibody response and B cell migration
  • role in astrocyte function, suggesting that modulation of this receptor may be beneficial in neuroinflammatory disorders
  • oxysterols and GPR183 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
  • is an important chemotactic receptor that is involved in proper B-cell T-cell interactions
  • GPR183 directs B-cell migration in the lymphoid follicles in response to its endogenous ligands, oxysterols
  • is a promoter of B-cell malignancies
  • mediator of CNS autoimmunity with contribution to the migration of autoreactive T cells into inflamed organs
  • governs localization of T cells, B cells, and dendritic cells (DCs) during immune responses in secondary lymphoid organs
  • role for GPR183 in promoting efficient thymic central tolerance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
  • GPR183 signaling serves as an indispensable switch for hematopoietic stem and progenitor cells (HSPCs) emergence by repressing NOTCH1 signaling before the onset of endothelial-to-hematopoietic transition (EHT)
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a chemotactic receptor for B, T and dendritic cells (DC)
  • augments T follicular helper (Tfh) cell fate by promoting interaction with IL2-quenching dendritic cells
  • GPR183 expression is directly influenced by Epstein-Barr virus (EBV) infection
  • cell & other
    REGULATION
    activated by activated by several oxysterol
    by specific oxysterols leading to chemotaxis of B cells in lymphoid tissues
    induced by Espstein-Barr virus
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS