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FLASH GENE
Symbol RBBP6 contributors: mct - updated : 28-06-2022
HGNC name retinoblastoma binding protein 6
HGNC id 9889
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 6858 - 1792 - 2019 31274515
  • regulate TP53 through its ubiquitin ligase activity, thus implicating in cell cycle regulation and apoptosis
  • isoforms 1 and 2 are multidomain proteins containing a domain with no name (DWNN) domain, a Zinc Finger, a RING Finger, an Rb-binding domain and a TP53-binding domain
  • 17 - 6756 - 1758 - 2019 31274515
  • isoforms 1 and 2 are multidomain proteins containing a domain with no name (DWNN) domain, a Zinc Finger, a RING Finger, an Rb-binding domain and a TP53-binding domain
  • 3 - 1784 - 118 - 2019 31274515
  • comprises the DWNN domain only
  • reported as a cell cycle regulator with anticancer potential
  • is a cell cycle regulator and may be de-regulated in carcinogenesis
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a lot of short repetitive sequences, in its central region
  • a ring-type zinc finger
  • unusual ubiquitin-like domain, DWNN ("domain with no name"), that is required for 3' processing activity
  • HOMOLOGY
    interspecies ortholog to murine Rbbp6
    homolog to rattus Rn.61207
    homolog to zebrafish Dr.18039
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having potential functional roles in the control of gene expression and mitosis
  • may modulate translation by influencing ribosomal protein gene expression
  • RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control
  • RBBP6 and isoform 3 are novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs
  • is implicated in esophageal, lung, hepatocellular and colon cancers
  • cancer-related protein that has been implicated in the regulation of cell cycle and apoptosis
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    text regulation of cell cycle
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to underphosphorylated RB1, and TP53
  • E3 ubiquitin ligase RBBP6 ubiquitinates and destabilizes the transcriptional repressor ZBTB38, and this pathway ensures genome-wide DNA replication and chromosomal stability
  • interacts with TP53 and enhances the activity of MDM2, the prototypical negative regulator of TP53
  • bound and ubiquitylated IKBKA, an inhibitor of the NFKB1-signaling pathway
  • likely RBBP6 interacts with the WDR33 and CPSF3 subunits of CPSF, and thus, it is likely that the role of RBBP6 is conserved from yeast to humans
  • cell & other
    REGULATION
    Other translationally regulated by PUM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    indicated poor prognosis in patients with non-small cell lung cancer (NSCLC) and this may be due to the ability of RBBP6 to promote cancer cell proliferation
    tumoral     --over  
    in colorectal cancer (CRC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be an important biomarker for cancer diagnosis
  • may be a potential prognostic biomarker for colorectal cancer
  • may (CRC) be a potential prognostic biomarker for non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential drug target for cancer treatment
    cancerlung 
    therapeutic target for NSCLC
    cancerdigestivecolon
    therapeutic target for CRC invasion and metastasis
    ANIMAL & CELL MODELS