basic FUNCTION
| rhodopsin-like receptor activity |
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is a pH sensor with an important role in regulating acid secretion in the kidney collecting duct |
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GPR4 activation by an acidic pH inhibits tumor cell migration and invasion |
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acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/RAPGEF3 pathway and may play a role in the inflammatory response of vascular endothelial cells |
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GPR4, GPR65 and GPR68 are G protein-coupled receptors that aid cells to sense and survive conditions of acidic pH |
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GPR4, GPR68, GPR65, GPR132 are regulators of cell proliferation and migration during tumor growth and wound healing |
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proton-sensing G protein-coupled receptor and an acid sensor in brain, kidney, and blood vessels |