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FLASH GENE
Symbol DEGS1 contributors: mct - updated : 27-10-2012
HGNC name degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
HGNC id 13709
RNA
TRANSCRIPTS type messenger
text Variants 1 and 2 encode the same isoform
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 2101 37 323 - 2002 11937514
- splicing 1681 37 323 - 2002 11937514
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three histidine containing consensus motifs
HOMOLOGY
interspecies homolog to Drosophila melanogaster des-1
Homologene
FAMILY spingolipid delta 4 desaturase fgamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • inserting double bonds at delta 4 position in fatty acids
  • involvement in cell cycle progression in human neuroblastoma cells
  • enzyme responsible for generating ceramide from its precursor dihydroceramide and thus controling synthesis of the bioactive lipid ceramide
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other oxidative stress leads to potent inhibition of dihydroceramide desaturase resulting in significant elevation in dihydroceramide levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS