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FLASH GENE
Symbol DCD contributors: - updated : 06-01-2006
HGNC name dermcidin
HGNC id 14669
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainpons  
Reproductivefemale systembreastmammary gland  
Skin/Tegumentskin    
 skin appendagesskin glandsweat glandeccrine sweat gland 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermisstratum corneum 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion sweat
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to lacritin
Homologene
FAMILY
CATEGORY regulatory , secretory , protooncogene
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • broad spectrum, antimicrobial peptide, playing a role in the regulation of human skin flora
  • playing a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immunity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mn2+ binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in invasive breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS