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FLASH GENE
Symbol CYP2B6 contributors: SGE/npt - updated : 13-08-2009
HGNC name cytochrome P450, family 2, subfamily B, polypeptide 6
HGNC id 2615
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3052 - 491 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
 liver   highly
Respiratorylung    
 respiratory tracttrachea   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
HOMOLOGY
Homologene
FAMILY
  • cytochrome P450 subfamily B
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenase
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • monooxygenase which catalyze many reactions involved in drug metabolism, synthesis of cholesterol, steroids and other lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with CYP2A6 (Ring 2007)
  • PGRMC1 binds to POR, which may influence CYP2B6 activity
  • PGRMC1 negatively modulates the drug-metabolizing activities of CYP2B6 through direct interaction
  • cell & other
    REGULATION
    induced by vitamin D receptor pathway
    phenobarbital and cyclophosphamide
    Other phosphorylation is accompanied by a decrease in enzyme activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS