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FLASH GENE
Symbol TXLNG contributors: mct - updated : 22-12-2012
HGNC name taxilin gamma
HGNC id 18578
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4418 - 528 - 2004 15184072
8 - 4022 - 396 - 2004 15184072
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an iq domain
  • lacking a basic DNA-binding domain but containing three leucine zippers
  • a myosin head-like domain
  • a rodlike tail sequence highly repetitive, showing cycles of a 28-AA repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • may be playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
  • regulating bone mass accrual and acting as a novel transcriptional regulator of osteoblastic function
  • its inhibition of expression increases ATF4 activity and confirm the important role of TXLNG in osteoblast function
  • inhibits transcriptional activation by a FOSL1/JUN heterodimer without affecting transcription mediated by a JUN homodimer
  • can both modulate early osteoblast activity by interacting with ATF4 and regulate later osteoblast function through inhibition of FOSL1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATF4 (to inhibit binding of ATF4 to DNA and block ATF4-mediated transcription of the osteocalcin gene)
  • could also potentially interact with additional basic domain-leucine zipper transcriptional regulators of osteoblast activity, such as FOSL1 (interaction is mediated through the second leucine zipper of TXLNG)
  • functional interaction between ATF4, TXLNG, and NACA, three proteins that have been previously shown to associate using various protein-protein interaction assays
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS