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FLASH GENE
Symbol COG6 contributors: mct/ - updated : 12-09-2023
HGNC name component of oligomeric Golgi complex 6
HGNC id 18621
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 5257 - 615 - 2002 11980916
19 - 3627 - 657 - 2002 11980916
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Visualeyelens   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text stem cells, placenta, fetal spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , oligo
HOMOLOGY
interspecies ortholog to murine Cog6
ortholog to rattus Cog6
Homologene
FAMILY
  • COG6 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • required for normal golgi function
  • directly involved in trafficking and maintenance of Golgi glycosylation machinery
  • facilitates T cell development and function, and when overexpressed, may contribute to immune dysfunction in Down syndrome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric Golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2L , SHNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS