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FLASH GENE
Symbol CMTM5 contributors: mct/npt - updated : 19-12-2009
HGNC name CKLF-like MARVEL transmembrane domain containing 5
HGNC id 19176
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing codon stop 1217 17.4 156 - Han, Guo (2009), Shao (2007)
  • variant 1
  • broadly expressed in normal adult and fetal tissues, but undetectable or down-regulated in most carcinoma cell lines and promoter methylation was detected in virtually all the silenced or down-regulated cell lines
  • - splicing codon stop 2171 14.2 129 brain Han
    containing an additional segment in the coding region
    4 - 1121 - 125 - Guo (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     spinal cord    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • chemokine-like factor gene superfamily
  • CMTM family (which belongs to TM4SF)
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • exhibits tumor suppressor activities, but with frequent epigenetic inactivation in carcinoma cell lines (Shao 2007)
  • may play a role in the pancreatic cancer (Guo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    undetectable in pancreatic cancer cell lines with promoter methylation and decreased in pancreatic cancer tissues (Guo 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS