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FLASH GENE
Symbol MGME1 contributors: mct - updated : 22-06-2015
HGNC name mitochondrial genome maintenance exonuclease 1
HGNC id 16205
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2142 39.3 344 - 2013 23313956
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY PD-(D/E)XK superfamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • mitochondrially localized metal-dependent DNase lacking detectable ribonuclease activity
  • mitochondrial RecB-type exonuclease, that cleaves single-stranded DNA and processes DNA flap substrates
  • MGME1-mediated mtDNA processing is essential for mitochondrial genome maintenance
  • mitochondrial exonuclease found to be involved in the processing of mitochondrial DNA (mtDNA) during replication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the mitochondrial replicase POLG, suggesting that it is a constituent of the mitochondrial replisome, to which it provides an additional exonuclease activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTDPS11
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS