Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MRGBP contributors: mct - updated : 31-01-2017
HGNC name MRG domain binding protein
HGNC id 15866
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2845 22.3 204 - 2003 12963728
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • has an important function in proliferation of cancer cells through the regulation of BRD8
  • contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells
  • shares little sequence and structural similarity with PHF12, yet targets similar pockets on the surface of the MRG domain, mimicking PHF12 in its interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of TRRAP/TIP60-containing histone acetyltransferase complex
  • member of the KAT5/NuA4 histone acetyltransferase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MORF4L1 and MORF4L2 proteins are MRGBP-associating proteins
  • MRFAP1 may regulate the ability of MORF4L1 to interact with chromatin-modifying enzymes by binding to MORF4L1 in a mutually exclusive manner with MRGBP
  • VEZF1 interacts with MORF4L1/MRGBP, a protein that recognizes H3K36 trimethylation, consistent with the role of histone modifications at alternatively spliced sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of colorectal tumors, and the enhanced expression was associated with cell proliferation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    should be a novel therapeutic target for colorectal cancer
    ANIMAL & CELL MODELS