Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BCO2 contributors: mct - updated : 30-03-2015
HGNC name beta-carotene oxygenase 2
HGNC id 18503
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2925 - 579 - -
10 - 2706 - 506 - -
12 - 2813 - 545 - -
12 - 2795 - 539 - -
11 - 2608 - 474 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Visualeyeretina    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Bcdo2
homolog to Drosophila RPE65
homolog to C.elegans F53C3.12
Homologene
FAMILY
  • carotenoid oxygenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalysing oxydation of beta-carotene by incorporation of two atoms of oxygen from molecular oxygen
  • mitochondrial carotenoid-oxygenase with broad substrate specificity
  • is a crucial protective component against oxidative stress and a mitochondrial carotenoid scavenger and a gatekeeper of the intrinsic apoptotic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Bco2 knockout mice, unlike WT mice, accumulate zeaxanthin in their retinas
  • in Bcdo2-deficient mice, carotenoid homeostasis was abrogated, and carotenoids accumulated in several tissues