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FLASH GENE

Symbol

ARL4A

contributors: mct/npt/pgu - updated : 03-02-2010

HGNC name	ADP-ribosylation factor-like 4A
HGNC id	695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005738 2 - 3162 NP_005729 22 200 - 2007 17398095 all variants encode the same protein NM_212460 2 - 2954 NP_997625 22 200 - 2007 17398095 NM_001037164 2 - 2957 22 200 - 2007 17398095

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Endocrine pancreas       moderately Nervous brain       moderately Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a GTPase domain

mono polymer

homomer , monomer

HOMOLOGY

interspecies	ortholog to murine Arl4
	homolog to Drosophila CG2219
	homolog to C.elegans F57H12.1

Homologene

FAMILY	ARF/ARL GTPase family
	ADP-ribosylation factors (ARF) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleolus
text	GCC2 and ARL4A localize to the Golgi independently of each other

basic FUNCTION	having a GTPase activity
	with ARL4C, and ARL4D, are able to recruit CYTH2 and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form
	alters the integrity of the Golgi structure by facilitating the interaction of GCC2 with CLASP1 and CLASP2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

GCC2 acts as a new effector for ARL4A to modulate Golgi organization

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS