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FLASH GENE
Symbol AQP10 contributors: mct/npt/pgu - updated : 25-08-2012
HGNC name aquaporin 10
HGNC id 16029
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1794 31.6 301 - 2011 21733844
  • a different sixth transmembrane domain
  • - - - 35 264 - 2011 21733844
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestinejejunum specific Homo sapiens
     intestinesmall intestineduodenum specific Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytosolic N-terminus
  • six membrane-spanning domain
  • three N-linked glycosylation sequons
  • N-glycosylation signals
  • a C-loop that is the longest of the human aquaporins
  • HOMOLOGY
    interspecies homolog to AQP9
    intraspecies homolog to AQP3,AQP9
    Homologene
    FAMILY
  • aquaglyceroporin family
  • MIP/aquaporin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • localized on the apical compartment of the intestinal epithelium called the glycocalyx
  • located in the apical membrane of enterocytes and is believed to contribute to the passage of water and glycerol through these intestinal absorptive cells
  • basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water
  • may be contribute to water transport in the upper portion of small intestine
  • involvement of a carrier-mediated mechanism in glycerol transport by AQP10
  • uniquely dual functional characteristic of AQP10 as a carrier/channel for solute transport
  • transmembrane facilitator of both water and glycerol transport in the small intestine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS