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FLASH GENE
Symbol ZRANB1 contributors: mct/npt - updated : 15-12-2021
HGNC name zinc finger, RAN-binding domain containing 1
HGNC id 18224
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4942 - 708 - 2021 33853758
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinelarge intestinecolon moderately
Endocrinethyroid   moderately
Nervousnerve   predominantly
Reproductivefemale systemovary  moderately
 female systemuterus  moderately
Respiratorylung   moderately
 respiratory tracttrachea  highly
Urinarykidney   moderately
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ankyrin-repeat Ub-binding domain is required for Lys29 and Lys33 linkage specificity
  • an ankyrin-repeat ubiquitin-binding domain determines ZRANB1 specificity for atypical ubiquitin chains
  • three RANBP2-type zinc fingers (three tandem NZF motifs)
  • one OTU domain
  • HOMOLOGY
    interspecies homolog to murine Zranb1 (99 pc)
    intraspecies homolog to A20
    Homologene
    FAMILY
  • peptidase C64 family
  • OTU domain deubiquitinase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • modulating TNF alpha signaling
  • may have a function in stem cell self-renewal or differentiation (Tran 2008)
  • specifically hydrolyzes both Lys29- and Lys33-linked diubiquitin
  • is an innate immunological regulator of inflammatory T cell responses
  • is a previously unrecognized inhibitor of hepatocellular carcinoma progression and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with TRAF6
  • can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription (Tran 2008)
  • ZRANB1 is the EZH2 deubiquitinase, and binds, deubiquitinates, and stabilizes EZH2
  • E3 ubiquitin ligase HECTD1 is a substrate of ZRANB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with poorer survival in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a new candidate prognostic biomarker for HCC treatment
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    therapeutic potential for targeting ZRANB1 in breast cancer
    ANIMAL & CELL MODELS