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FLASH GENE
Symbol DSCAML1 contributors: mct - updated : 07-12-2011
HGNC name Down syndrome cell adhesion molecule like 1
HGNC id 14656
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
33 - 6899 - 2113 - 2002 12051741
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrainhindbraincerebellum highly
 braindiencephalonhypothalamus highly
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
nervousbrain
nervouscerebellum
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text developing spinal cord, cortex
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten immunoglobulin domains
  • six fibronectin three domains
  • one extracellular domain
  • HOMOLOGY
    interspecies homolog to murine Dscaml1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the formation and maintenance of neural networks
  • DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Dscaml1 had fasciculated rod bipolar cell dendrites and clumped AII amacrine cell bodies, also indicating a role in self-avoidance