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FLASH GENE

Symbol

FAM3C

contributors: SGE/npt - updated : 10-09-2009

HGNC name	family with sequence similarity 3, member C
HGNC id	18664

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	Alternate transcriptional splice variants that encode the same protein were characterized

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014888.2 10 - 2552 NP_055703 24.7 227 - - NM_001040020.1 10 - 2512 NP_001035109 24 227 - -

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine small intestine     lowly   liver       highly Endocrine pancreas       highly Lymphoid/Immune spleen       lowly Nervous brain       highly Reproductive female system placenta     highly   female system ovary     lowly   male system testis     lowly   male system prostate     lowly Respiratory lung       moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately

cells

System Cell Pubmed Species Stage Rna symbol Skeleton osteoblast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a GG domain
	a hydrophobic leader sequence
	an N-terminal signal peptide
	4-helix bundle

HOMOLOGY

interspecies	ortholog to fam3c, Danio rerio
	ortholog to Fam3c, Mus musculus
	ortholog to Fam3c, Rattus norvegicus
	homolog to LOC463680, Pan troglodytes

intraspecies

homolog to FAM3A

Homologene

FAMILY

FAM3 family

CATEGORY

secretory , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
text	secreted

basic FUNCTION	FAM3C is a tumor- and metastasis-inducing protein cooperates with oncogenic Ras to cause and maintain TGF-b-independent epithelial to mesenchymal transition (EMT) of hepatocyte (Lahsnig et al 2009)
	collaboration of FAM3C with oncogenic Ras enhances tumor formation, nuclear accumulation of b-catenin and Stat3 tyrosine phosphorylation (Lahsnig et al 2009)
	play a role in the EMT regulation
	may be involved in retinal laminar formation processes (Katahira 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	cooperates with oncogenic Ras
	ILEI stimulates upregulation of PDGF-C/PDGF-Rb and enhances proliferation and migration in oncogenic Ras-expressing MIM-R-GFP hepatocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS