basic FUNCTION
| inhibiting the formation of actin stress fibers, membrane ruffles and integrin-based focal adhesions |
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inducing loss of cell-substrate adhesion leading to cell rounding |
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inducing the Rac-dependant neuritic process formation in part by disruption of the cortical actin filament |
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controling rearrangements of the actin cytoskeleton |
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causing the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments |
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implicated in the regulation of neurite outgrowth, dendrite development, and axon guidance |
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enhancing the microtubule destabilizing activity of STMN2 and both proteins colocalize in neurons |
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involved in the guidance of axons by interacting with the cytoplasmic domain of plexins, which form the signaling subunit of semaphorin receptors |
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affects actin dynamics antagonistically to RHO and has been implicated in the regulation of neurite outgrowth, dendrite development, and axon guidance |
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RND1, RND2, and RND3 are well known as key regulators of the actin cytoskeleton in various cell types, but they comprise a distinct subgroup of the RHO family in that they are GTP bound and constitutively active (pMID: 22357615) |
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induces a loss of stress fibres and weakening of cell-cell junctions |
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restrains activation of Ras-MAPK signalling and breast tumour initiation and progression |