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FLASH GENE

Symbol

CDK5RAP3

contributors: mct/npt/pgu - updated : 09-05-2017

HGNC name	CDK5 regulatory subunit associated protein 3
HGNC id	18673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_176096 14 - 1884 NP_788276 - 506 - 2007 17549666

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine pancreas       highly Homo sapiens Lymphoid/Immune spleen       highly   thymus       highly Nervous brain       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to Drosophila CG4826

Homologene

FAMILY

CDK5RAP3 family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION

basic FUNCTION	may be involved in the regulation of cell proliferation
	regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
	having TP53-dependent cell-cycle effects that are independent of ARF
	inhibit cellular proliferation and clonogenic growth
	playing a role in NF-kappaB regulation and tumor suppression
	potentiates DNA damage-induced cell death by modulating the G2/M checkpoint
	novel negative regulator of checkpoint response, and by counteracting CHEK1, promotes CDC2 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response
	putative tumor suppressor that plays important roles in multiple cell signaling pathways, including DNA damage response and NF-kappaB signaling
	UFL1, like CDK5RAP3, also plays an important role in regulation of NF-kappaB signaling and cell invasion
	putative tumor suppressor that inhibits RELA, CHEK1 and CHEK2 and activates TP53
	its activity includes inhibition of MAPK14 phosphorylation and activation
	CDK5RAP3 binding to the substrate is not required for potentiated PPM1D catalytic activity and directly binds PPM1D to augment its phosphatase activity

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	components of the UFM1 conjugation pathway (UFM1, DDRGK1, UFL1 and CDK5RAP3)
	CDK5RAP3 and UFL1 may form a large protein complex

INTERACTION

DNA

RNA

small molecule

protein	bind to the CDK5 activator p35
	interacts with endogenous ARF (can regulate ARF biochemical and biological activity)
	regulator of CDC2 activation
	interacts with CHEK1 and antagonizes its function
	binds MAPK14, alters its cellular localization, and inhibits basal and cytokine-stimulated MAPK14 activity
	CDK5RAP3 binds PPM1D and stimulates its phosphatase activity

cell & other

REGULATION

Other

phosphorylated by NCLK

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CCNB2, AGER, CDK5RAP3, may be used as a very reliable biomarker of lung adenocarcinoma
Therapy target

ANIMAL & CELL MODELS