basic FUNCTION
| acting at the centromere to establish a connection with the spindle for proper chromosome segregation |
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required for the spindle checkpoint |
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kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006) |
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required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore |
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having a necessary role for correct binding of spindle checkpoint proteins to kinetochore (act independent of each other in kinetochore assembly, but their combined activities are required for checkpoint signaling) |
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kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006) |
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directly connects kinetochores to spindle microtubules (Wilson-Kubalek 2008) |