SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,heterochromosome
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nucleus,nucleolus
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| intracellular,nuclear envelope
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text
| localizes to heterochromatin in interphase cells but is liberated from chromosomal arms at the onset of mitosis |
basic FUNCTION
| may interact with lamin B receptor (LBR) to contribute to the association of the heterochromatin with the inner nuclear membrane |
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mediating gene silencing |
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is released from chromatin during the M phase of the cell cycle, upon H3 serine 10 phosphorylation |
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chromatin-associated protein, effector of SUMO-dependent changes in chromatin structure and gene expression |
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is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins |
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recruited to the BIRC5 promoter in a DNMT1-dependent manner, thus mediating silencing of euchromatic genes |
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involved in transient repression of inducible promoters |
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essential role in heterochromatin formation and mitotic progression through its interaction with various proteins |
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heterochromatin-associated protein localizing to pericentromeres and telomeres, which has a dose-dependent effect on gene silencing, and a critical role in heterochromatin formation and maintenance |
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with ORC3 and ORC2, may be recruited to the chromatin as a single complex and require each other for their stable association to heterochromatin |
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with ORC2, are required for condensation of centric heterochromatic satellite repeats |
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novel role during the cellular response to oxidative stress |
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potentially acts as a rapid redox sensor, and it may connect the intracellular redox state with transcriptional regulation under various physiological conditions |
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in homology-directed repair (HDR) is linked to the DNA-end resection step of DNA breaks, through the promotion of RPA loading and phosphorylation at damage site |
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promotes nucleosome associations that drive chromatin condensation |
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phosphorylation-dephosphorylation cycle of CBX5 orchestrates accurate progression of cells through mitosis |
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chromosomal protein that binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures |
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is involved in regulation of chromatin plasticity, DNA damage repair, and centromere dynamics |
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essential link between CBX5-interacting molecular dynamics and chromosome plasticity in promoting accurate cell division |
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evolutionary conserved protein that binds histone H3 di- or tri-methylated at position lysine 9 (H3K9me2/3), a hallmark for heterochromatin, and has an essential role in forming higher order chromatin structures |
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involved in the epigenetic regulation of gene silencing |
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plays an important role in the differentiation and angiogenic function of endothelial stem/progenitor cells (EPCs) by regulating endothelial gene expression |
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CBX5-oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform |
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WDR76 co-localizes to puncta with the heterochromatin proteins CBX1 and CBX5, which are also recruited to DNA damage but much less intensely than WDR76 |
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is a gene that mediates chromatin conformation, gene silencing and cancer progression |
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specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation |
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forms and maintains the domains of heterochromatin through the interaction of its chromodomain with trimethylated lysine 9 of histone 3, although this interaction is not the sole determinant |