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FLASH GENE
Symbol CDC14B contributors: mct - updated : 15-02-2012
HGNC name CDC14 cell division cycle 14 homolog B (S. cerevisiae)
HGNC id 1719
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 splicing 5472 52.8 459 - 2005 15911625
14 splicing 5589 56.8 498 - 2005 15911625
  • CDC14B-I2
  • lacking the last 11 aa as compared to isoform 1
  • containing additional 50 aa at the C terminus as compared to isoform 1
  • 14 splicing 5131 54.2 471 - 2005 15911625
  • CDC14B-I3
  • lacking the last 11 aa as compared to isoform 1
  • containing additional 23 aa at the C terminus as compared to isoform 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    contains a protein-tyrosine phosphatase domain
    HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Cdc14
    homolog to Drosophila CG7134
    homolog to C.elegans C17G10.4c
    intraspecies homolog to CDC14A
    Homologene
    FAMILY dual specificity protein tyrosine phosphatase family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • in response to genotoxic stress in G2, the phosphatase, translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase FZR1, with the consequent degradation of PLK1, a prominent mitotic kinase
  • a fraction of CDC14B associates with centrosomes
  • basic FUNCTION
  • involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control
  • potential function in maintaining the fidelity of centrosome duplication cycle
  • has a central function in the G2 DNA damage checkpoint, and is potentially required for efficient DNA repair
  • serves a critical role in regulating progression through mitosis, which is distinct from CDC14A
  • CDC14B-dependent modulation of CDC25C phosphatase and CDK1 activity is tightly linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability
  • disrupting the cytoskeletal F-actin organization with loss of actin stress fibers and vinculin adhesions in a phosphatase-dependent manner
  • phosphatase displaying oncogenic activity mediated by the Ras-Mek signaling pathway
  • redundancy between CDC14B and CDC14A in DNA Double-Strand Break Repair repair
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TP53
  • CHEK1 substrate (interplay between CHEK1 kinase and CDC14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability)
  • CDH1 is a downstream target of CDC14B in DSB repair
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS