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FLASH GENE
Symbol CATSPER1 contributors: mct - updated : 22-03-2019
HGNC name cation channel, sperm associated 1
HGNC id 17116
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2634 - 780 - 2015 26453676
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatozoa Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single, six-transmembrane-spanning repeat with a P loop between transmembrane domains S5 and S6
  • an intracellular N-terminal histidine-rich region
  • a predicted calcium-selective pore region
  • six-transmembrane-spanning repeat of the voltage-dependent Ca2+-channel four-repeat structure (
  • HOMOLOGY
    interspecies ortholog to Catsper1, Mus musculus
    ortholog to Catsper1, <<
    Homologene
    FAMILY
  • cation channel sperm-associated family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text restricted to the plasma membrane of spermatozoa above the fibrous sheath in the principal piece of the sperm tail
    basic FUNCTION
  • being vital to cAMP-mediated calcium influx in sperm, sperm mobility and fertilization
  • having required roles in male fertility
  • required for Ca2+ entry into the flagellum and for Ca2+-mediated hyperactivated sperm motility
  • CATSPER channel complex serves as a polymodal sensor for multiple chemical cues that assist sperm during their voyage across the female genital tract
  • CATSPER1, CATSPER2 are voltage-dependent calcium channels located in the plasma membrane of the sperm flagellum and is responsible for triggering hyperactive motility
  • encodes a pore-forming and pH-sensing subunit of the CATSPER Ca2+- permeable channel, a protein in the flagellum essential for sperm hyperactivation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS reproduction/sex
    text cation channel (voltage-gated- channel)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • voltage-gated calcium channel Ca(v)3.3 (
  • molecular mechanism responsible for activation of CATSPER1, CATSPER2 by progesterone arises early in sperm development concurrently with the CATSPER channel itself
  • transcription factors SOX5 and SOX9 caused a significant increase in transactivation of the CATSPER1 promoter in heterologous systems, and both transcription factors interact with the CATSPER1 promoter
  • critical role of LRRC52 in CATSPER1 channels and loss of a non-pore-forming auxiliary subunit results in severe fertility impairment
  • CRISP1 has the ability to regulate CATSPER1, the principal sperm Ca(2+) channel involved in hyperactivation and essential for fertility
  • transcriptional factor SRY specifically binds to different sites in the promoter sequence and has the ability to control CATSPER1 gene transcription
  • CRISP2 can bind to the CATSPER1 subunit of the Catsper ion channel which is required for normal sperm motility
  • cell & other
    REGULATION
    activated by in response to intracellular alkalinization, increasing the concentration of intraflagellar calcium and thereby inducing hyperactivity of psermatozoa
    progesterone and alkaline pH (
    ASSOCIATED DISORDERS
    corresponding disease(s) NSMI
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    impairs the phase of motility of spermatozoa
    constitutional       loss of function
    loss of CATSPER1 function is sufficient to compromise fertilizing capacity of human spermatozoa
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    blocking CATSPER1 activity could be useful as a male contraceptive
    ANIMAL & CELL MODELS
    Catsper 1 knock-out mice leads male sterility: sperm motility is decreased markedly in CatSper-/- mice, and CatSper-/- sperm are unable to fertilize intact eggs