basic FUNCTION
| playing a role in the calcium/calmodulin-dependent (CaM) kinase cascade |
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phosphorylating CAMK1, CAMK1D, CAMK1G and CAMK4 |
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involved in regulating cell apoptosis |
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promoting cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death |
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stimulates glucose uptake via insulin-independent signaling mechanisms |
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implicated in the regulation of skeletal muscle glucose uptake independent of PRKAB1 and AKT1 activation |
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important new role for CAMKK1 in the differentiation of monocytic cells |
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capable of activating BRSK1 through phosphorylation of Thr (189)and CaMKK1 may be an alternative activating kinase for BRSK1 |
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CAMKK1-induced phosphorylation of DNM1L regulates mitochondrial morphology ( |
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act as regulatory enzymes for downstream protein kinases in various Ca2+-dependent cellular processes |
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mediates potentially novel Ca2+-signaling pathway(s), which are independent of downstream protein kinases |