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FLASH GENE
Symbol ATP11C contributors: mct - updated : 17-12-2011
HGNC name ATPase, Class VI, type 11C
HGNC id 13554
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 6128 129 1132 - 2004 15533723
29 - 6023 128 1119 - 2004 15533723
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
haloacid dehalogenase-like hydrolase domain
HOMOLOGY
interspecies homolog to Drosophila CG17034
homolog to C.elegans Y49E10.11
Homologene
FAMILY
  • the cation transport ATpases (P-type) family
  • type IV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • magnesium-dependent enzyme catalyzing the hydrolysis of ATP coupled with the transport of calcium
  • critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
  • essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development
  • multifunctional transporter, essential for adult B-cell development, the prevention of intrahepatic cholestasis, and parturition
  • key nonhematopoietic role for ATP11C, specifically in the prevention of intrahepatic cholestasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate for genetically undiagnosed cases of cholestasis and dystocia in humans
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mutation of the X-linked mouse gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes hyperbilirubinemia