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FLASH GENE
Symbol CRIP2 contributors: mct - updated : 28-01-2012
HGNC name cysteine-rich protein 2
HGNC id 2361
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1236 22.5 208 - 1996 8824798
- - 1700 - - testis 1996 8824798
EXPRESSION
Rna function
  • detected abundantly in developing and adult hearts
  • Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
     vessel     Homo sapiens
    Digestiveintestinesmall intestine  highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunespleen   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
     gangliaautonomic ganglia  highly Homo sapiens
    Olfactory (smell)olfactory bulb     Homo sapiens
    Reproductivefemale systemovary  highly Homo sapiens
     male systemtestis  highly Homo sapiens
     male systemprostate  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningendothelium   Homo sapiens
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines tumor associated endothetial cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cysteine rich motifs
  • two LIM zinc-binding domains
  • lacks the DNA-binding LIM domain
  • HOMOLOGY
    interspecies homolog to rattus Esp1or CRP2
    Homologene
    FAMILY
  • cysteine-rich intestine protein family l and specifically to the second class of LIM domain proteins
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,nucleus
    text
  • in the cardiomyocytes, colocalized with cardiac troponin T in the thin-filaments of sarcomeres
  • predominantly localized in the cytoplasm of olfactory precursor cells
  • expressed in the nucleus
  • basic FUNCTION
  • involved in transcription
  • acting as a regulator of alpha-actinin function
  • acts as a transcription repressor of the NFKB–mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis
  • functional role of CRIP2 in cancer development and crucial role in regulating angiogenesis during tumor development
  • regulates NFKB transcriptional activity by inhibiting its binding to the promoter region
  • might exert an important impact on the cardiovascular development, maintenance and homeostasis
  • play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • interacting with WNT3A (WNT3A regulates the development of cardiac neural crest cells by modulating expression of CRIP2 in rhombomere 6)
  • association with ADAM19 through its disintegrin (DI) domain, a cysteine-rich (Cys) domains (ADAM19 promotes the secretion of CRIP2)
  • cell & other
    REGULATION
    Other regulation of CRIP2 localization by the development of actin fibers during smooth muscle cell differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL14QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    induces apoptosis through induction of active caspases 3 and 9 proteins in esophageal squamous cell carcinoma
    tumoral     --low  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene for ID in del14qter
    Marker
    Therapy target
    ANIMAL & CELL MODELS