protein
| binding to RAB GTPase (such as VPS21) |
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binding to ubiquitin (Ub binding is necessary for the recruitment of RABGEF1 to early endosomes, and this recruitment is independent of its GEF activity and of its partners, RAB5 and RABEP1) |
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RAB22A is a binding site on early endosomes for direct recruitment of RABGEF1 and activation of RAB5A, establishing a RAB22A-RAB5A signaling relay to promote early endosome fusion |
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positive feedback activation of RAB5A by RABGEF1 and RABEP1 in endocytosis with a delayed onset |
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functions as an E3 ligase for RAS |
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interaction of RABGEF1 with RAB5A depends specifically on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization |
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GEF activity of RABGEF1 is crucial for recruiting RAB5A |
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corecruitment of RAB5A to the same structures to which RABGEF1 is mistargeted offers strong support for the idea that RABGEF1 localization determines RAB5A membrane localization |
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APBB1IP is a critical component of the phagocytosis machinery downstream of RABGEF1 and mediates its function by recruiting talin to the phagocytic complement receptors |
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in the absence of F11R, the exchange factors RABGEF3 and RAPGEF4 are down-regulated, which prevents the activation of the small GTPase RABGEF1 |
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RASA3 targets RAS and RABGEF1 |
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P2RY12 signaling is required to inhibit RASA3 and enable sustained RABGEF1-dependent platelet activation and thrombus formation at sites of vascular injury |
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RABEP1 is recruited by both RABGEF1 recognizing ubiquitylated cargo and by RAB4A to activate RAB5A in a feed-forward manner |
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role of the RABGEF1-APBB1IP, in leukocyte integrin activation and consequently in leukocyte trafficking |
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TBC1D21 may likely interact with and potentially regulate RABGEF1 during spermatogenesis |