protein
| interaction with BLOC-3, interaction mediated by HPS4 and the switch I and II regions of RAB9A |
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RAB9A stability on late endosomes required interaction with PLIN3 |
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GCC2 ia a RAB9A effector that is required for Mannose 6-phosphate receptor recycling from endosomes to the TGN in living cells |
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RAB9A binding did not influence GAP activity of bead-bound SGSM2 protein |
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SGSM1 is a TBC domain-containing protein that binds to RAB9A specifically but is not a GAP for RAB9A |
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RAB9B can bind to SGSM1 probably in a similar manner as RAB9A |
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potential involvement of RAB9A in the regulation of the SGSM2 localization and in the trafficking of melanogenic enzymes (RAB32, RAB38, TYRP1) |
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RAB9A, competes with the catalytic subunit PPP2CA in binding to PPP2R1A, which has an important role in controlling the PPP2CA catalytic activity, compromised in several solid tumors and leukemias |
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HPS4 is required for activation of RAB32/RAB38 GTPases in melanogenesis, but its RAB9 activity is dispensable for melanogenesis |