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FLASH GENE
Symbol RAB3D contributors: mct/ - updated : 07-12-2011
HGNC name RAB3D, member RAS oncogene family
HGNC id 9779
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4290 - 219 - 1999 10023084
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
 stomach   highly
Endocrineadrenal glandcortex  highly
 pancreas   highly
 thyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Skeletonosteoclast Homo sapiens
cell lineage
cell lines constitutively and lowly expressed in all hematopoietic cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to murine Rab3d
homolog to Drosophila rab3
homolog to C.elegans rab-3
Homologene
FAMILY
  • small GTPase superfamily
  • Rab3 subfamily (Rab3A/B/C/D) of small exocytotic GTPases
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • DYNLT1 and RAB3D intimately associate with the dynein motor complex and microtubules in osteoclasts
  • basic FUNCTION
  • involved in regulated exocytosis
  • RAB3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range
  • implication of myosin Va and RAB3D in the maturation of SGs (secretory granules) where they participate in overlapping but not identical tasks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , exocytosis transport
    text vesicle transport; hemocyte development
    PATHWAY
    metabolism
    signaling
    a component
  • components of the RAB3D-trafficking pathway contribute to the maintenance of osteoclastic resorptive function
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • interaction between RAB3D and PIGR implicated in trafficking through regulated secretory vesicles in lacrimal gland acinar cells
  • DYNLT1 is a RAB3D-interacting partner (binds specifically to RAB3D in a GTP-dependent manner and co-occupies RAB3D-bearing vesicles in bone-resorbing osteoclasts)
  • cell & other
    REGULATION
    induced by BHLHA15 transcription factor
    Other activated in myeloid differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS