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FLASH GENE
Symbol RAB11B contributors: mct - updated : 02-02-2017
HGNC name RAB11B, member RAS oncogene family
HGNC id 9761
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1635 - 218 - 2003 14627637
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartventricle    Homo sapiens
Digestivesalivary gland   highly Homo sapiens
Nervousbrain   predominantly Homo sapiens
 nervecranial nerve  highlyHomo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiacmyocardium  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four conserved domains important for GTP binding the C terminus involved in membrane association
  • conjugated LipoP , Other
    HOMOLOGY
    interspecies homolog to murine Rab11b
    homolog to Drosophila rab11
    homolog to C.elegans rab11.1
    homolog to yeast ypt3
    intraspecies homolog to RAB11A
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized to peri-centrosomal recycling endosomes concentrated at the base of the cilium
  • basic FUNCTION
  • involved in vesicle transport
  • having GTPase activity
  • having a specific role in neuronal and neuroendocrine but not in non-neuronal cells as a GTP-dependent switch between regulated and constitutive secretory pathways
  • having divergent functions in Ca2+-regulated versus constitutive exocytosis
  • implicated in the regulation of vesicular trafficking between the recycling endosome compartment and early endosomes to the trans Golgi network and plasma membrane
  • regulates apical recycling in polarized epithelial cells
  • RAB11B is a crucial regulator and RAB11FIP5 is a mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland
  • regulator of endosomal recycling
  • differentially regulates the trafficking of distinct cargo and extends our understanding of how endosomal transport impacts the functional expression of L-type Ca(2+) channels
  • regulates the trafficking and recycling of SCNN1A
  • predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by RAB11B through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • RAB11B is necessary for the trafficking of PRKG2 and the cGMP/PRKG2 signaling pathway is closely related to RAB11B recycling pathway
  • RAB11B and its effector RAB11FIP5 participate in insulin granule exocytosis and RAB11FIP5, as a substrate of PKA, regulates the potentiation of exocytosis by cAMP in pancreatic beta-cells
  • is a crucial regulator and RAB11FIP5 as mediator of acidosis-induced ATP6V1A traffic in duct cells of submandibular gland
  • RAB11B has a moderate association with a region of KCNMA1 that includes AA 127–616 and this interaction of RAB11B and KCNMA1 is in cochlea
  • RAB3IL1 is a dual RAB-binding protein that could potentially link RAB3A and RAB11A/RAB11B and/or RAB8A/RAB8B and RAB11-mediated intracellular trafficking processes
  • LZ doamin of PRKG2 specifically interacted with RAB11B
  • RAB11B is a critical regulator of F2R trafficking
  • RAB11A and RAB11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
  • is a direct interactor of the ciliary RAB RABIN8
  • interaction between TBC1D8B and RAB11B, a key protein in vesicular recycling in cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDASCW
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS