involved in controling the assembly of other splicing-regulatory proteins
enhancing the binding of two other proteins (hnRNPH and KSRP) to the DCS RNA
possible retinal autoantigen of cancer-associated retinopathy (CAR)
potential trans-acting factor that helps to stabilize PGK2 mRNA in male germ cells
post-transcriptional switch from PTBP1 to PTBP2 controls a widespread alternative splicing program during neuronal development
promoting pre-mRNA 3' end processing in collaboration with hnRNPH
PTBP1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by PTBP2
potential role for PTBP2 in neurogenesis
PTBP1 and its brainspecific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport
controls a genetic program essential for neuronal maturation
PTBP2 is required for alternative splicing regulation in the testis, as in brain
functions as a key regulator of alternative pre-mRNA splicing in the nucleoplasm and promotes internal ribosome entry site-mediated translation initiation of viral and cellular mRNAs in the cytoplasm
PTBP1 and PTBP2, are also nonconserved cryptic exon repressors and PTBP1 and PTBP2, are also nonconserved cryptic exon repressors, and PTBP1 and PTBP2 are members of a family of cryptic exon repressors
PTBP1 and PTBP2 reprogram developmental pre-mRNA splicing in neurons
PTBP1 and PTBP2 serve both specific and redundant functions in neuronal pre-mRNA splicing
PTBP2 controls a network of genes involved in cell adhesion, migration, and polarity, suggesting that splicing regulation by PTBP2 is critical for germ cell communication with Sertoli cells
is a key alternative splicing regulator for male germ cell development
is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia
necessary and sufficient to convert non-neuronal cells to the neuronal lineage
is a new possible target for chronic myeloid leukemia (CML) and progressive inclusion/exclusion of PTBP2 exon 10 might play an important role in CML progression
PTBP2-orchestrated alternative splicing programming is required for robust generation of a single axon in mammals
PTBP1, PTBP2 are essential for B cell development
CELLULAR PROCESS
cell life, differentiation
PHYSIOLOGICAL PROCESS
text
differentiation of hematopoietic cells
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
binding to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS)
binding to the HBB 3'UTR
small molecule
protein
TP53 internal ribosome entry sites (IRES) interacting trans-acting factor (PTBP2 binds specifically to both the TP53 IRESs but with differential affinity)
CELF1 interacts with PTB proteins (PTBP1, PTBP2) (CELF1 and PTB proteins modulate the inclusion of TPM2 exon 6B during myogenic differentiation)
interacts with AICDA (PTBP2 is thus an effector of class-switch recombination that promotes the binding of AICDA to switch-region DNA)
re-expression of PTBP1 or PTBP2 in differentiated neurons inhibited DLG4 expression and impaired the development of glutamatergic synapses