basic FUNCTION
| key regulator of RB1 gene expression |
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functions as a regulatory node to couple two important signaling pathways to regulate cell growth and survival during mouse embryogenesis |
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enhancing the transcriptional activation of the p21 promoter by PIAS4 whereas PIAS4 transcription activity is severely reduced upon RB1CC1 depletion by RNA interference |
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tumor suppressor implicated in the regulation of RB1 (retinoblastoma 1) expression |
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autophagy factor that functions together with ULK1 and ULK2 |
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crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways |
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playing a role in the regulation of neuronal homeostasis through its function in autophagy |
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may play a role in homeostasis of neurons |
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key intrinsic regulator of fetal hematopoietic stem cells (HSCs) and implicate a potential role for autophagy in the maintenance of fetal hematopoiesis and HSCs |
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essentially requires binding with SMARCB1, a chromatin-remodeling factor) to activate the CDKN2A promoter, in order to enhance the RB1 pathway and acts as a tumor suppressor |
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new function in the regulation of DNA damage response and cell survival through its activity in autophagy |
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with ATG13, act in concert during autophagy induction |
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caused suppression of type II collagen synthesis in the differentiated chondrocytes through multimodal signaling involving Erk suppression and NFKB activation |
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role for RB1CC1 in tumor suppression in the presence of APC dysfunction |
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essential for autophagy induction in mammalian cells, resulting in a progressive loss of neural stem cells |
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RB1CC1-mediated autophagy contributes to the maintenance and functions of neural stem cells through regulation of oxidative state |