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FLASH GENE
Symbol ARFGAP2 contributors: mct/npt - updated : 13/09/2008
HGNC name ADP-ribosylation factor GTPase activating protein 2
HGNC id 13504
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2803 56 521 - Watson (2004)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain   highly
Reproductivefemale systembreast   
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
reproductivemammary gland
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila aef1
    homolog to yeast gcs-1
    homolog to C.elegans C55B7.12
    ortholog to murine Znf289
    ortholog to yeast Glo3p
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    text predominantly cytoplasmic
    basic FUNCTION
  • mediator of ID1 induced proliferation pathway in mammary epithelial cells
  • ARFGAP2 and ARFGAP3 are coat protein-dependent ArfGAPs
  • control guanosine triphosphate (GTP) hydrolysis on the small G protein ADP-ribosylation factor ARF1 at the Golgi apparatus
  • ARFGAP1, ARFGAP2, and ARFGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport
  • function with ARFGAP2 in COP I traffic
  • follow the dynamic behavior of coatomer upon stimulation of vesicle budding
  • ARFGAP2 and ARFGAP3 seem to be essential for the formation of the vesicle promoting coat lattice
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    activated by ID1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS