protein
| binding C-terminal tail domain of UCHL5, and relieved the autoinhibition |
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proteasome interacting protein |
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interaction between ATP6V0D2 and ADRM1 (Kim 2009) |
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interacting with UCHL5 (Nishio 2009) |
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phosphorylated TP63 induces transcription of ADRM1, leading to NOS2 protein degradation |
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UCHL5 is a de-ubiquitinating enzyme that is activated by ADRM1 and involved in the proteasomal degradation of proteins |
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interaction of PSMD1 with ADRM1 is controlled by SUMOylation in a manner that may alter proteasome composition and function |
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ADMR1 can activate UCHL5 by disrupting dimerization, although physiologically relevant activation likely results from stabilization of a surface competent for ubiquitin binding and modulation of the active-site crossover loop |
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binding of SGTA to ADRM1 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation |
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ADRM1 plays an important role in mediating removal of mutant Htt aggregates when excess HAPF8A140 is present |
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direct interaction between SGTA and the proteasome, mediated by the intrinsic proteasomal ubiquitin receptor ADRM1 (27827410) |
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is recruited to the proteasome through direct interaction with the large scaffolding protein PSMD1 within the 19S regulatory particle |
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binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors |
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PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics |
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F8A1 -mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction |