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FLASH GENE
Symbol CD177 contributors: mct - updated : 28-11-2017
HGNC name CD177 antigen
HGNC id 30072
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
cell lineage erythroblasts, megakaryocytes, promyelocytes, and myelocytes lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • two highly homologous 188-residue cysteine-rich domains that share homology with UPAR domains
  • a highly hydrophobic C-terminal sequence probably encoding a GPI link
  • three N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY uPAR/CD59/Ly6 family of cell surface receptors
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION involved in the pathogenesis of immune neutropenias and transfusion reactions
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in neutrophils of patients with polycythemia vera and essential thrombocytemia
             
    Alloimmunization to the neutrophil antigen NB1 (HNA-2a, CD177) can result in neonatal immune neutropenia and transfusion-related acute lung injury
    constitutional     --over  
    increased mRNA levels of both PRTN3 and CD177 in ANCA)-associated systemic vasculitis (AASV)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS