basic FUNCTION
| may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion |
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ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme |
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displays antiangiogenic properties and protect the host toward tumor progression |
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ADAMTS12, independent of its proteolytic activity, plays a specific, non-redundant role in trophoblast invasion |
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ADAMTS7 and ADAMTS12 appear to be potent negative regulators of endplate cartilage development |
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is a degradative enzyme that interacts with the degradable fragments of cartilage oligomeric matrix protein, which is a prominent non-collagenous matrix component in articular cartilage |
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ADAMTS12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis |