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FLASH GENE
Symbol SLC22A9 contributors: mct - updated : 07-01-2021
HGNC name solute carrier family 22 (organic anion/cation transporter), member 9
HGNC id 16261
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2327 - 553 - 2001 11327718
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains (12TM), with cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • uptake of fetal derived steroid sulfatin by trophoblast
  • mediated Na(+)-independent, high-affinity transport of sulfate-conjugated steroids, estrone sulfate, and dehydroepiandrosterone sulfate
  • involved in the transport of anionic substances such as sulfate-conjugates in exchange for butyrate in hepatocytes
  • with SLC22A12, are key transporters in renal reabsorption of perfluorocarboxylates
  • marked interindividual variability likely in the hepatic expression of SLC22A7/SLC22A9, which may contribute to the pharmacokinetic variability of their substrates
  • OATS4 (SLC22A9, SLC22A10, SLC2A24, and SLC22A25) members are specifically associated with conjugated sex hormones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transactivated by hepatocyte nuclear factor-1 (HNF-1A)
  • HNF4A is a major transcriptional regulator of SLC22A9 (
  • pravastatin is the first identified SLC22A9 drug substrate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS