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FLASH GENE
Symbol SSX2IP contributors: mct - updated : 04-01-2017
HGNC name synovial sarcoma, X breakpoint 2 interacting protein
HGNC id 16509
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5658 - 614 - Nousiainen (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ER retention motif
  • nuclear localization signal (NLS)
  • three coiled-coil domains
  • one P-loop motif
  • HOMOLOGY
    Homologene
    FAMILY
  • SSX family, MSD1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus
    text
  • colocalizes with afadin at adherens junctions (AJs) and was also detectable at the perinuclear regions, probably the Golgi complex
  • localizes to the basal body of primary cilia in human and murine ciliated cells
  • basic FUNCTION
  • actin filament (F-actin)-binding protein associated with the cytoplasmic tail of nectin, a Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecule
  • may be involved in organization of the actin cytoskeleton at cell-cell adherens junctions (AJs) through afadin and alpha-actinin
  • involved in vesicle trafficking from the Golgi to the endoplasmic reticulum and through the Golgi complex by interacting with the coatomer complex
  • centriolar satellite protein, playing a role in the assembly of primary cilia
  • is a novel targeting factor for ciliary membrane proteins cooperating with CEP290, the BBSome, and RAB8A
  • is delivered to the centrosome in a centriolar satellite-dependent manner and binds the microtubule-nucleator gamma-tubulin complex
  • is essential for ciliogenesis
  • SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication
  • conserved spindle anchoring protein
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • binding alpha-actinin, an F-actin-bundling protein known to be indirectly associated with E-cadherin through its direct binding to alpha-catenin
  • SSX2IP mediates the activation of RAC1 through VAV2
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myeloid leukaemia cells.
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS