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FLASH GENE
Symbol RAB3IP contributors: npt/mct - updated : 17-06-2016
HGNC name RAB3A interacting protein (rabin3)
HGNC id 16508
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 9517 51 460 - 2002 12007189
  • RAB3IP-A1
  • 11 - 9651 - 476 - 2002 12007189
  • RAB3IP-A2
  • 10 - 9417 - 395 - 2002 12007189
  • RAB3IP-B1
  • 10 - 9551 - 411 - 2002 12007189
    RAB3IP-B2
    - - - - 304 - 2002 12007189
    - - - - 320 - 2002 12007189
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, thymus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one ER retention motif
  • one coiled-coil domain
  • one nuclear localization signal (NLS)
  • the GEF domain RAB3IP display the minimal targeting machinery for recruiting their cognate RABs (RAB1A and RAB8A, respectively) to the mitochondrial membrane
  • HOMOLOGY
    interspecies homolog to rattus Rabin3
    Homologene
    FAMILY
  • SEC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized to the cortical actin (Hattula 2002)
    basic FUNCTION
  • involved in mediating polarized membrane transport (Hattula 2005)
  • having exchange activity on RAB8A and RAB8B but not on RAB3A (Hattula 2002)
  • Rab8-specific activator that is connected to processes that mediate polarized membrane traffic to dynamic cell surface structures (Hattula 2002)
  • is a direct phospho-substrate of ERK1/2 in response to EGF signaling, and ERK1/2 activate RAB3IP to regulate vesicular trafficking to the plasma membrane in response to extracellular signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RAB3IP, RAB10, and the microtubule minus-end-directed kinesin KIFC3 form a peroxisome-associated complex to control the movement of peroxisomes along microtubules, enabling communication between peroxisomes and ciliary pocket membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • bind RAB8A and function as nucleotide exchange factors for Rab8 but not for RAB3A and RAB5 (Hattula 2005)
  • ASAP1 serves as a scaffold that brings together the proteins necessary for transport to the cilia including the GTP-binding protein ARF4 and the two G proteins of the Rab family--RAB11A and RAB8A--linked by the RAB8A guanine nucleotide exchange factor RAB3IP
  • components of the vesicular transport machinery, the GEF RAB3IP and the GTPase RAB8A, are interacting partners of CEP164
  • RAB11FIP3 coordinates the interactions of ASAP1 and RAB11A with RAB3IP
  • RAB11FIP3 acts synergistically with ASAP1 to direct RAB3IP in ciliary receptor targeting
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS