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FLASH GENE
Symbol EPN3 contributors: mct - updated : 27-04-2012
HGNC name epsin 3
HGNC id 18235
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3944 - 632 - 2003 12750376
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins)
  • two or three ubiquitin-interacting motifs (UIMs)
  • two clathrin binding sequences
  • HOMOLOGY
    interspecies homolog to rattus Epsin
    homolog to Drosophila CG7646
    homolog to C.elegans ncs-2
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • co-localized with clathrin
  • nuclear accumulation when nuclear export inhibited
  • basic FUNCTION
  • may serve an important function in activated epithelial cells during tissue morphogenesis
  • participatong in clathrin-mediated synaptic vesicle
  • endocytosis at a central synapse
  • endocytic adapter protein, regulating mitotic membrane morphology and spindle integrity (PMID;
  • epsin-induced membrane curvature is required for proper spindle morphogenesis, independent of its function in endocytosis during interphase (PMID;
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by extracellular matrix in cells following contact with fibrillar type 1 collagen
    Other downregulated following cell differentiation (expression spatially and temporally regulated)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS