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FLASH GENE
Symbol ENAH contributors: npt/mct/pgu - updated : 24-02-2009
HGNC name enabled homolog (Drosophila)
HGNC id 18271
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - - - - 2008 18676769
  • contains an additional exon corresponding to 21 AAs located in the EVH2 domain, from a breast carcinoma cell line of epithelial phenotype
  • specifically associated with an epithelial phenotype, EGFR dependency, and sensitivity to erlotinib (Pino 2008)
  • role in coupling multiple signaling pathways involved in breast cancer
  • activated by EGFR in breast cancer cell lines
  • 15 - 13172 66.4 591 - 2008 19081071
    14 - 13109 63.8 570 - 2007 18158903
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ENA/VASP homology domain (EVH1) at the N terminus
  • an arg-leu-glu-rich region
  • a pro-rich profilin binding motif
  • C terminal EVH2 domain
  • HOMOLOGY
    interspecies homolog to murine enabled homolog
    ortholog to drosophila Ena
    Homologene
    FAMILY
  • Ena/VASP family
  • enabled/vasodilator-stimulated phosphoprotein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulating lamellipodial dynamics and actin network
  • actin regulatory protein involved in the control of cell motility and adhesion, and modulated during human breast carcinogenesis
  • have a role beyond anticapping activity in filopodia formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of the EVH1 domain with FPPPP sequence motifs found in a variety of cytoskeletal proteins, including lamellipodin, vinculin, and zyxin
  • ZYX recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • interaction with ABI1 (promotes the ABL-mediated phosphorylation of ENAH by binding both ABL and ENAH)
  • by mediating intensive F-actin accumulation at the sites of cell infiltration, WASF2, WASL, and ENAH are crucial for PI3K-dependent cell invasion induced by PDGFA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-risk benign breast lesions and primary and metastatic tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS